Defontis Myriam, Richartz Janina, Engelmann Nina, Bauer Christian, Schwierk Viktoria Maria, Büscher Philippe, Moritz Andreas
Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig University Giessen, Giessen, Germany.
Vet Clin Pathol. 2012 Sep;41(3):369-74. doi: 10.1111/j.1939-165X.2012.00454.x.
A 9-year-old male Jack Russell Terrier with a history of travel to Thailand was presented with chronic lethargy, weight loss, unilateral anterior uveitis, pancytopenia, hyperglobulinemia, and proteinuria. Numerous trypomastigotes were found on a blood smear, and using molecular methods the parasite was identified as Trypanosoma evansi. After initial response to treatment, the dog experienced a relapse with central neurologic signs 88 days after initial presentation and died. Antibodies to T evansi were detected in both serum and cerebrospinal fluid (CSF) using a card agglutination test (CATT/T evansi), and PCR analysis of CSF for T evansi was positive. Findings at necropsy included marked non-purulent meningoencephalitis. Chronic infection with T evansi in a dog that returned to Germany following international travel highlights the risk associated with introduction of foreign animal diseases to Europe and the possibility of these infections becoming endemic. Detection of chronic infection and curative therapy of trypanosomiasis are challenging, and infection is usually fatal in the dog.
一只9岁的雄性杰克罗素梗犬有前往泰国的旅行史，出现慢性嗜睡、体重减轻、单侧前葡萄膜炎、全血细胞减少、高球蛋白血症和蛋白尿。在血涂片上发现了大量锥虫鞭毛体，通过分子方法鉴定该寄生虫为伊氏锥虫。在对治疗产生初始反应后，这只狗在初次就诊88天后出现中枢神经症状复发并死亡。使用卡片凝集试验（CATT/T evansi）在血清和脑脊液（CSF）中均检测到了抗伊氏锥虫抗体，并且对脑脊液进行伊氏锥虫的PCR分析呈阳性。尸检结果包括明显的非化脓性脑膜脑炎。一只国际旅行后返回德国的犬只感染伊氏锥虫的慢性感染病例，凸显了将外来动物疾病引入欧洲的风险以及这些感染成为地方病的可能性。检测慢性感染和治疗锥虫病具有挑战性，并且感染在犬中通常是致命的。
