Giordani Federica, Morrison Liam J, Rowan Tim G, DE Koning Harry P, Barrett Michael P
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow,Glasgow G12 8TA,UK.
Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh,Easter Bush,Midlothian EH25 9RG,UK.
Parasitology. 2016 Dec;143(14):1862-1889. doi: 10.1017/S0031182016001268. Epub 2016 Oct 10.
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.
几个世纪以来，感染家畜的致病性动物锥虫一直是非洲农业发展的主要制约因素，并且在南美洲和亚洲，它们的负面经济影响正在增加。化学疗法和化学预防是主要的控制手段。然而，几十年来，对新型杀锥虫剂的研究一直不足，导致由于耐药寄生虫的出现，现有的少数化合物正在失去效力。在这篇综述中，我们全面概述了目前可用于治疗和预防动物锥虫病的方法，特别关注耐药性问题。还介绍了围绕主要具有经济重要性的动物锥虫物种及其引起的疾病的关键问题。随着有新的投资用于开发更好的控制动物锥虫病的工具，我们强调应努力更好地了解相关寄生虫物种和菌株的生物学特性，以确定新的药物靶点并探究耐药机制。
