RTI International, San Francisco, CA, USA.
Ann Epidemiol. 2012 Nov;22(11):753-8. doi: 10.1016/j.annepidem.2012.08.004. Epub 2012 Sep 3.
Pregnancy and childbirth are normal conditions, but complications and adverse outcomes are common. Both genetic and environmental factors influence the course of pregnancy. Genetic epidemiologic research into pregnancy outcomes could be strengthened by the use of common measures, which would allow data from different studies to be combined or compared. Here, we introduce perinatal researchers to the PhenX Toolkit and the Collections related to pregnancy and childbirth.
The Pregnancy and Birth Collections were drawn from measures in the PhenX Tooklit. The lead author selected a list of measures for each Collection, which was reviewed by the remaining authors and revised on the basis of their comments. We chose the measures we thought were most relevant for perinatal research and had been linked most strongly to perinatal outcomes.
The Pregnancy and Birth Health Conditions Collection includes 24 measures related to pregnancy and fertility history, maternal complications, and infant complications. The Pregnancy and Birth Outcome Risk Factors Collection includes 43 measures of chemical, medical, psychosocial, and personal factors associated with pregnancy outcomes.
The biological complexity of pregnancy and its sensitivity to environmental and genomic influences suggest that multidisciplinary approaches are needed to generate new insights or practical interventions. To fully exploit new research methods and resources, we encourage the biomedical research community to adopt standard measures to facilitate pooled or meta-analyses.
妊娠和分娩是正常的生理状态，但并发症和不良结局较为常见。遗传和环境因素均会影响妊娠过程。对妊娠结局进行遗传流行病学研究，可以采用通用的测量方法来加强研究，从而能够合并或比较来自不同研究的数据。在这里，我们向围产期研究人员介绍 PhenX 工具包以及与妊娠和分娩相关的集合。
妊娠和分娩集合从 PhenX 工具包中的测量方法中提取。主要作者为每个集合选择了一组测量方法，其余作者对该列表进行了审查，并根据意见进行了修订。我们选择了我们认为与围产期研究最相关、与围产期结局关联最紧密的测量方法。
妊娠和分娩健康状况集合包括 24 项与妊娠和生育史、孕产妇并发症以及婴儿并发症相关的测量方法。妊娠和分娩结局风险因素集合包括 43 项与妊娠结局相关的化学、医疗、心理社会和个人因素的测量方法。
妊娠的生物学复杂性及其对环境和基因组影响的敏感性表明，需要采用多学科方法来产生新的见解或实际干预措施。为了充分利用新的研究方法和资源，我们鼓励生物医学研究界采用标准测量方法，以促进合并或荟萃分析。
