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重链和轻链：肌球蛋白在心脏形态发生中的作用。

Heavy and light roles: myosin in the morphogenesis of the heart.

机构信息

School of Biomedical Sciences, University of Nottingham, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK.

出版信息

Cell Mol Life Sci. 2013 Apr;70(7):1221-39. doi: 10.1007/s00018-012-1131-1. Epub 2012 Sep 6.

DOI:10.1007/s00018-012-1131-1
PMID:22955375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3602621/
Abstract

Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain and myosin light-chain proteins are required for a correctly formed heart. Myosins are structural proteins that are not only expressed from early stages of heart development, but when mutated in humans they may give rise to congenital heart defects. This review will discuss the roles of myosin, specifically with regards to the developing heart. The expression of each myosin protein will be described, and the effects that altering expression has on the heart in embryogenesis in different animal models will be discussed. The human molecular genetics of the myosins will also be reviewed.

摘要

肌球蛋白是心肌的重要组成部分，从心脏发生到成年心脏都有它的存在。尽管传统上肌球蛋白因其在能量转导和力的产生中的作用而闻名，但最近的研究表明，肌球蛋白重链和肌球蛋白轻链蛋白对于形成正常的心脏都是必需的。肌球蛋白是结构蛋白，不仅在心脏发育的早期阶段表达，而且在人类中发生突变时，可能导致先天性心脏缺陷。本综述将讨论肌球蛋白的作用，特别是在发育中的心脏。将描述每种肌球蛋白蛋白的表达，并讨论在不同动物模型的胚胎发生中改变表达对心脏的影响。还将回顾肌球蛋白的人类分子遗传学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/3da9dc782e28/18_2012_1131_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/502b49250025/18_2012_1131_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/1e5ea0164d75/18_2012_1131_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/7d909e368fa4/18_2012_1131_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/465903eda43d/18_2012_1131_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/3da9dc782e28/18_2012_1131_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/502b49250025/18_2012_1131_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/1e5ea0164d75/18_2012_1131_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/7d909e368fa4/18_2012_1131_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/465903eda43d/18_2012_1131_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5407/11113738/3da9dc782e28/18_2012_1131_Fig5_HTML.jpg

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