Price J, Grunhaus L J
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0118.
J Clin Psychiatry. 1990 Jan;51(1):32-3.
Clomipramine (a tricyclic antidepressant with significant serotonin activity) causes a high incidence of anorgasmia. The authors describe the successful treatment of clomipramine-induced anorgasmia with yohimbine (an enhancer of norepinephrine activity) in a patient with obsessive compulsive disorder and major depression. The significance of this finding for the clinical management of antidepressant-induced sexual dysfunction and the impact of serotonergic-noradrenergic interaction on male sexual functioning are discussed.
