Quirk K C, Einarson T R
Can J Psychiatry. 1982 Apr;27(3):228-31. doi: 10.1177/070674378202700311.
Three cases of orgasmic inhibition by clomipramine are reported, one in a male and two in females. All were depressed patients with obsessive-compulsive features. Orgasmic dysfunction manifested shortly after beginning clomipramine therapy despite a return of libido as the depression lifted. Two of these patients switched to desipramine which led to a resolution of sexual dysfunction while maintaining the patients depression free. The third patient manipulated dosage times to diminish the orgastic problem. Strong anticholinergic and/or anti-adrenergic properties of clomipramine are suspected to underlie the development of this problem.
报告了3例由氯米帕明引起性高潮抑制的病例，其中男性1例，女性2例。所有患者均为患有强迫症状的抑郁症患者。尽管随着抑郁症状缓解性欲有所恢复，但性高潮功能障碍在开始氯米帕明治疗后不久就出现了。其中2例患者换用去甲丙咪嗪后，性功能障碍得到解决，同时患者保持无抑郁状态。第3例患者通过调整服药时间来减轻性高潮问题。怀疑氯米帕明强大的抗胆碱能和/或抗肾上腺素能特性是导致该问题的原因。
