Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Inflammopharmacology. 2013 Oct;21(5):377-83. doi: 10.1007/s10787-012-0147-3. Epub 2012 Sep 7.
The present study has evaluated the healing effects of extract of dried fruit pulp of Terminalia chebula (TCE) on acetic acid (AA)-induced colitis in rats. TCE (600 mg/kg) showed healing effects against AA-induced colonic damage score and weight when administered orally daily for 14 days. TCE was further studied for its effects on various physical (mucus/blood in stool and stool frequency, food and water intake and body weight changes), histology, antibacterial activity and free radicals (NO and LPO), antioxidants (SOD, CAT and GSH) and myeloperoxidase in colonic tissue. Intra-colonic AA administration increased colonic mucosal damage and inflammation, mucus/bloody diarrhoea, stool frequency, but decreased body weight which were reversed by TCE and sulfasalazine (SS, positive control) treatments. TCE showed antibacterial activity and both TCE and SS enhanced the antioxidants, but decreased free radicals and myeloperoxidase activities affected in acetic acid-induced colitis. TCE indicated the presence of active principles with proven antioxidants, anti-inflammatory, immunomodulatory, and free radical scavenging and healing properties. Thus, TCE seemed to be safe and effective in healing experimental colitis.
本研究评估了诃子干果浆提取物（TCE）对乙酸（AA）诱导的大鼠结肠炎的治疗作用。TCE（600mg/kg）经口每日给药 14 天，对 AA 诱导的结肠损伤评分和体重具有治疗作用。进一步研究了 TCE 对粪便中粘液/血液、粪便频率、食物和水摄入量以及体重变化等各种生理指标、组织学、抗菌活性和自由基（NO 和 LPO）、抗氧化剂（SOD、CAT 和 GSH）以及结肠组织中髓过氧化物酶的影响。AA 直肠内给药增加了结肠粘膜损伤和炎症、粘液/血性腹泻、粪便频率，但降低了体重，TCE 和柳氮磺胺吡啶（SS，阳性对照）治疗可逆转这些变化。TCE 表现出抗菌活性，TCE 和 SS 均可增强抗氧化剂，但降低 AA 诱导的结肠炎中受影响的自由基和髓过氧化物酶活性。TCE 表明其含有具有抗氧化、抗炎、免疫调节、清除自由基和愈合作用的有效成分。因此，TCE 似乎对治疗实验性结肠炎是安全有效的。
