Department of Pediatrics, University of Chieti, Via Dei Vestini 5, 66013 Chieti, Italy.
Eur J Endocrinol. 2012 Dec;167(6):749-58. doi: 10.1530/EJE-12-0699. Epub 2012 Sep 6.
In this review, we will try to analyze the possible coexistence between epilepsy or seizures and type 1 diabetes mellitus (T1DM), in order to establish if there is more than a casual association, and to investigate possible mechanisms underlying this link. Anti-glutamic acid decarboxylase antibodies (GAD-Abs) have been associated with T1DM and a great number of neurological diseases such as epilepsy. Epilepsy can be a feature of a large variety of autoimmune or inflammatory disorders. GAD-Abs can have a role at the basis of the possible link between epilepsy and T1DM, although their real pathogenetic mechanism in neurological diseases is still unknown. Metabolic conditions such as hypoglycemia and hyperglycemia, common problems in diabetic patients, may be also implicated, even if their underlying mechanism is minimally understood.
在这篇综述中，我们将尝试分析癫痫或发作与 1 型糖尿病（T1DM）之间可能共存的情况，以确定两者之间是否不仅仅是偶然的关联，并探讨这种联系背后可能存在的机制。谷氨酸脱羧酶抗体（GAD-Abs）与 T1DM 以及许多神经系统疾病如癫痫有关。癫痫可能是多种自身免疫或炎症性疾病的特征。GAD-Abs 可能在癫痫和 T1DM 之间的可能联系中起作用，尽管它们在神经系统疾病中的真正发病机制仍不清楚。代谢状况如低血糖和高血糖，糖尿病患者常见的问题，也可能与之相关，尽管其潜在机制尚不清楚。
