Research and Development Department, Dermal Laboratories Ltd, Hitchin.
Clin Cosmet Investig Dermatol. 2012;5:85-91. doi: 10.2147/CCID.S32642. Epub 2012 Aug 8.
Few studies have directly compared the effectiveness of different emollients in vivo, and the important matter of patient preference is generally overlooked.
We report the results of an assessor-blinded, bilateral, concurrent comparison of two emollient pharmaceutical presentations, ie, Doublebase gel (DB) and Aqueous cream BP (AC), applied by 20 participants three times daily for 7 consecutive days. The primary efficacy endpoint was cumulative improvement in skin hydration measured by corneometry on days 1, 3, and 5 immediately before the first application and approximately 2 hours after the third application of the day. Secondary endpoints were investigator assessment of skin condition at these time points and participant assessment of product acceptability at the end of the study.
Both products increased skin hydration, but the effect of AC was relatively modest, with morning values readily returning to pretreatment levels. Hydration levels were higher for DB gel, maintained at all time points, and showed stepwise, cumulative increases over the 7 days of use. Overall patient satisfaction scores were higher for DB gel, and especially for "consistency," "ease of use," and "ease of absorption into the skin." Eighty-five percent of participants expressed a desire to use DB gel again as compared with 40% for AC.
鲜有研究直接比较不同保湿剂的体内疗效，且患者偏好这一重要问题通常被忽视。
我们报告了一项评估者盲法、双侧、同期比较两种保湿剂药物制剂（即 Doublebase 凝胶[DB]和 Aqueous cream BP[AC]）的结果，20 名参与者每日双侧各使用 3 次，连续 7 天。主要疗效终点为使用第 1、3、5 天第 1 次和第 3 次使用约 2 小时后，通过皮肤角质层水分测量仪评估的皮肤水合作用累积改善。次要终点为这些时间点研究者评估的皮肤状况和研究结束时参与者对产品可接受性的评估。
两种产品均增加了皮肤水合作用，但 AC 的作用相对较小，早晨的数值很快恢复到治疗前水平。DB 凝胶的水合作用水平更高，在所有时间点均保持稳定，并在使用 7 天内呈逐步、累积增加。DB 凝胶的整体患者满意度评分更高，尤其是在“一致性”、“易用性”和“易于被皮肤吸收”方面。与 40%的 AC 相比，85%的参与者表示愿意再次使用 DB 凝胶。
