Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Br J Dermatol. 2010 Nov;163(5):954-8. doi: 10.1111/j.1365-2133.2010.09954.x.
Aqueous Cream BP is widely prescribed to patients with eczema to relieve skin dryness. The formulation contains sodium lauryl sulphate (SLS), a chemical that is a known skin irritant and a commonly used excipient in personal care and household products. The chronic effects of Aqueous Cream BP application on skin barrier function have not been determined.
To characterize and assess skin barrier function of healthy skin after application of Aqueous Cream BP and to study the physical effects of the formulation on the stratum corneum (SC).
The left and right volar forearms of six human volunteers were each separated into treated and control sides. The treated sides of each forearm were subjected to twice daily applications of Aqueous Cream BP for 4 weeks at the end of which concomitant tape stripping and transepidermal water loss (TEWL) measurements were made. The untreated sides of the forearms were not exposed to any products containing SLS during the study period.
Changes in SC thickness, baseline TEWL and rate of increase in TEWL during tape stripping were observed in skin treated with Aqueous Cream BP. The mean decrease in SC thickness was 1·1 μm (12%) (P = 0·0015) and the mean increase in baseline TEWL was 2·5 g m⁻² h⁻¹ (20%) (P < 0·0001). Reduced SC thickness and an increase in baseline TEWL, as well as a faster rate of increase in TEWL during tape stripping, were observed in 16 out of 27 treated skin sites.
The application of Aqueous Cream BP, containing ∼1% SLS, reduced the SC thickness of healthy skin and increased its permeability to water loss. These observations call into question the continued use of this emollient on the already compromised barrier of eczematous skin.
BP 水溶性乳膏被广泛开给湿疹患者以缓解皮肤干燥。该配方含有月桂基硫酸钠（SLS），这是一种已知的皮肤刺激性物质，也是个人护理和家庭用品中常用的赋形剂。目前尚未确定长期使用 BP 水溶性乳膏对皮肤屏障功能的影响。
描述和评估健康皮肤使用 BP 水溶性乳膏后的皮肤屏障功能，并研究该制剂对角质层（SC）的物理影响。
6 名志愿者的左右掌侧前臂分别分为治疗侧和对照侧。在研究结束时，治疗侧前臂每日两次涂抹 BP 水溶性乳膏，持续 4 周，同时进行胶带剥离和经皮水分丢失（TEWL）测量。研究期间，前臂的非治疗侧未接触任何含有 SLS 的产品。
在接受 BP 水溶性乳膏治疗的皮肤中，观察到 SC 厚度、基线 TEWL 和胶带剥离过程中 TEWL 增加率的变化。SC 厚度平均减少 1.1 μm（12%）（P = 0.0015），基线 TEWL 平均增加 2.5 g m ⁻² h ⁻¹（20%）（P < 0.0001）。在 27 个治疗皮肤部位中，有 16 个部位观察到 SC 厚度减小、基线 TEWL 增加以及胶带剥离过程中 TEWL 增加率加快。
含有约 1% SLS 的 BP 水溶性乳膏的应用降低了健康皮肤的 SC 厚度并增加了其对水分丢失的通透性。这些观察结果对在已经受损的湿疹皮肤屏障上继续使用这种赋形剂提出了质疑。
