Cork Michael J, Danby Simon
Sheffield Children's Hospital and Sheffield Teaching Hospitals, and School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield.
Br J Nurs. 2009;18(14):872, 874, 876-7. doi: 10.12968/bjon.2009.18.14.43356.
Breakdown of the skin barrier is the first event in the development of atopic eczema (atopic dermatitis). Research over the past five years has indicated that this arises as a result of the interaction of environmental agents such as soap and other detergents with the products of changes in several genes. These genetic changes predispose to the breakdown of the skin barrier, which allows the penetration of allergens, triggering a flare of atopic eczema. This new understanding of how breakdown of the skin barrier is the first event in the development of atopic eczema provides a rationale for a renaissance in the use of a complete emollient therapy regimen in atopic eczema and related skin barrier breakdown diseases, such as asteatotic eczema and irritant contact dermatitis.
皮肤屏障的破坏是特应性湿疹（特应性皮炎）发病过程中的首个事件。过去五年的研究表明，这是由于肥皂和其他洗涤剂等环境因素与多个基因变化的产物相互作用所致。这些基因变化易导致皮肤屏障破坏，使过敏原得以渗透，从而引发特应性湿疹发作。对皮肤屏障破坏是特应性湿疹发病首个事件的这一新认识，为在特应性湿疹及相关皮肤屏障破坏疾病（如乏脂性湿疹和刺激性接触性皮炎）中重新采用完整的润肤治疗方案提供了理论依据。
