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参与脑单胺神经递质系统在中药方剂——百合地黄汤抗抑郁样作用中的作用。

Involvement of the cerebral monoamine neurotransmitters system in antidepressant-like effects of a chinese herbal decoction, baihe dihuang tang, in mice model.

机构信息

Department of Clinical Pharmacology, General Hospital of Peoples Liberation Army, Beijing 100853, China.

出版信息

Evid Based Complement Alternat Med. 2012;2012:419257. doi: 10.1155/2012/419257. Epub 2012 Aug 23.

DOI:10.1155/2012/419257
PMID:22956973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3432930/
Abstract

Baihe Dihuang Tang (BDT) is a renowned Chinese herbal formula which is commonly used for treating patients with mental instability, absentmindedness, insomnia, deficient dysphoria, and other psychological diseases. These major symptoms closely associated with the depressive disorders. BDT was widely popular use for treating emotion-thought disorders for many years in China. In the present study, the antidepressant-like effect of BDT in mice was investigated by using the forced swim test (FST) and the tail suspension test (TST). The underlying mechanism was explored by determining the effect of BDT on the level of cerebral monoamine neurotransmitters. BDT (9 and 18 g/kg, p.o. for 14 days) administration significantly reduced the immobility time in both the FST and the TST without changing locomotion in the open field-test (OFT). Moreover, BDT treatment at the dose of 18 g/kg inhibited reserpine-induced ptosis. Meanwhile, BDT enhanced 5-HT and NA levels in mouse cerebrum as well as decreased the ratio of 5-HT compared to its metabolite, 5-HIAA, (turnover, 5-HIAA/5-HT) after TST. The results demonstrated that the antidepressant-like effect of BDT is mediated, at least partially, via the central monoaminergic neurotransmitter system.

摘要

百合地黄汤（BDT）是一种著名的中草药配方，常用于治疗精神不稳定、健忘、失眠、情志抑郁等心理疾病患者。这些主要症状与抑郁症密切相关。BDT 在中国多年来广泛用于治疗情绪思维障碍。在本研究中，通过强迫游泳试验（FST）和悬尾试验（TST）研究了 BDT 在小鼠中的抗抑郁样作用。通过测定 BDT 对脑单胺神经递质水平的影响，探讨了其作用机制。BDT（9 和 18 g/kg，口服 14 天）给药可显著减少 FST 和 TST 中的不动时间，而不改变旷场试验（OFT）中的运动。此外，BDT 治疗剂量为 18 g/kg 可抑制利血平引起的眼睑下垂。同时，BDT 增强了小鼠大脑中的 5-HT 和 NA 水平，并降低了 TST 后 5-HT 与其代谢物 5-HIAA 的比值（转化，5-HIAA/5-HT）。结果表明，BDT 的抗抑郁样作用至少部分是通过中枢单胺能神经递质系统介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/9c8c2d29495b/ECAM2012-419257.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/843d8075160d/ECAM2012-419257.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/6b513da5f135/ECAM2012-419257.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/924ccc7904af/ECAM2012-419257.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/9c8c2d29495b/ECAM2012-419257.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/843d8075160d/ECAM2012-419257.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/6b513da5f135/ECAM2012-419257.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/924ccc7904af/ECAM2012-419257.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fd9/3432930/9c8c2d29495b/ECAM2012-419257.004.jpg

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