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酸枣仁百合粉混悬液对大鼠抑郁样行为的治疗作用

Ziziphi spinosae lily powder suspension in the treatment of depression-like behaviors in rats.

作者信息

Wang Yifang, Huang Mei, Lu Xinyi, Wei Runze, Xu Jinyong

机构信息

The first clinical college, Anhui Medical University, Hefei, 230032, People's Republic of China.

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, People's Republic of China.

出版信息

BMC Complement Altern Med. 2017 Apr 28;17(1):238. doi: 10.1186/s12906-017-1749-5.

DOI:10.1186/s12906-017-1749-5
PMID:28454575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5410100/
Abstract

BACKGROUND

Depression is a chronic, recurring and potentially life-threatening illness. Current treatments for depression are characterized by a low success rate and associated with a wide variety of side effects. The aim of the present study was to evaluate the behavioral anti-depressant effect of a novel herbal compounds named ziziphi spinosae lily powder suspension, as well as to investigate its potential mechanisms.

METHODS

Except for body weight, depressive-like behaviors were also evaluated using forced swimming test, sucrose consumption test and open field test. In order to investigate the underlying potential mechanisms, serum 5-HT and brain 5-HIAA were measured using ultrahigh-performance liquid chromatography and high-performance liquid chromatography, respectively.

RESULTS

Results showed that the herbal compounds ziziphi spinosae lily suspension could alleviate depressive symptoms in rat model of chronic depression. Biochemical analysis revealed that the herbal compounds elevated serum 5-HT and brain 5-HIAA.

CONCLUSION

Ziziphi spinosae lily powder suspension could alleviate depressive behaviors in depression model animals. The underlying mechanisms may be related to the increase of serum 5-HT in peripheral blood and 5-HIAA in brain. The study provides important mechanistic insights into the protective effect of the herbal compounds against chronic depressive disorder and suggests that the herbal compounds may be a potential pharmacological agent for treatment of major depressive disorder.

摘要

背景

抑郁症是一种慢性、复发性且可能危及生命的疾病。目前的抑郁症治疗方法成功率低且伴有多种副作用。本研究的目的是评估一种名为酸枣仁百合粉混悬液的新型草药化合物的行为抗抑郁作用，并探究其潜在机制。

方法

除体重外，还使用强迫游泳试验、蔗糖消耗试验和旷场试验评估抑郁样行为。为了探究潜在机制，分别使用超高效液相色谱法和高效液相色谱法测量血清5-羟色胺（5-HT）和脑内5-羟吲哚乙酸（5-HIAA）。

结果

结果表明，草药化合物酸枣仁百合混悬液可减轻慢性抑郁症大鼠模型的抑郁症状。生化分析显示，该草药化合物可提高血清5-HT和脑内5-HIAA水平。

结论

酸枣仁百合粉混悬液可减轻抑郁症模型动物的抑郁行为。其潜在机制可能与外周血血清5-HT和脑内5-HIAA的增加有关。该研究为草药化合物对慢性抑郁症的保护作用提供了重要的机制见解，并表明该草药化合物可能是治疗重度抑郁症的潜在药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/78a8ff513cc2/12906_2017_1749_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/1813b2b8d72a/12906_2017_1749_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/2c5063bf811c/12906_2017_1749_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/887f620d906b/12906_2017_1749_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/612b10726fe8/12906_2017_1749_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/15825ce7e20e/12906_2017_1749_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/78a8ff513cc2/12906_2017_1749_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/1813b2b8d72a/12906_2017_1749_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/2c5063bf811c/12906_2017_1749_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/887f620d906b/12906_2017_1749_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/612b10726fe8/12906_2017_1749_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/15825ce7e20e/12906_2017_1749_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/5410100/78a8ff513cc2/12906_2017_1749_Fig6_HTML.jpg

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J Nutr Sci Vitaminol (Tokyo). 2016;62(3):206-12. doi: 10.3177/jnsv.62.206.
2
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J Agric Food Chem. 2015 Nov 11;63(44):9722-8. doi: 10.1021/acs.jafc.5b04078. Epub 2015 Oct 30.
3
Herbal Medicine for Anxiety, Depression and Insomnia.
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Int J Bipolar Disord. 2024 May 9;12(1):16. doi: 10.1186/s40345-024-00338-7.
4
Sour Jujube ( var. ): A Bibliometric Review of Its Bioactive Profile, Health Benefits and Trends in Food and Medicine Applications.酸枣（变种）：关于其生物活性特征、健康益处及食品与医药应用趋势的文献计量学综述
Foods. 2024 Feb 20;13(5):636. doi: 10.3390/foods13050636.
5
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Curr Drug Metab. 2024;25(1):71-80. doi: 10.2174/0113892002284230240213064248.
6
The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors.龙芽百合联合氟西汀对抑郁模型小鼠的抗抑郁作用机制。
NPJ Syst Biol Appl. 2024 Jan 13;10(1):5. doi: 10.1038/s41540-024-00329-5.
7
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PLoS One. 2023 Dec 1;18(12):e0294944. doi: 10.1371/journal.pone.0294944. eCollection 2023.
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6
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Psychiatry Res. 2015 Feb 28;225(3):509-14. doi: 10.1016/j.psychres.2014.11.056. Epub 2014 Dec 9.
7
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Physiol Behav. 2015 Feb;139:224-30. doi: 10.1016/j.physbeh.2014.11.049. Epub 2014 Nov 20.
8
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Pharmacogn Mag. 2014 Oct;10(40):509-16. doi: 10.4103/0973-1296.141777.
9
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10
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