新生儿坏死性小肠结肠炎的血液学异常
Haematological abnormalities in neonatal necrotizing enterocolitis.
作者信息
Song Rhonnie, Subbarao Girish C, Maheshwari Akhil
机构信息
Department of Pediatrics, Division of Neonatology, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
J Matern Fetal Neonatal Med. 2012 Oct;25 Suppl 4(0 4):22-5. doi: 10.3109/14767058.2012.715005.
Abstract
OBJECTIVE
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological abnormalities associated with NEC.
METHODS
A literature search was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies.
RESULTS
Thrombocytopenia, disseminated intravascular coagulation, increased or decreased neutrophil counts, and hemolytic anemia are frequent events in NEC.
CONCLUSIONS
NEC is associated with several hematological abnormalities, which may play a direct or indirect role in the pathogenesis of gut mucosal injury, and may also carry important prognostic information.
摘要
目的
坏死性小肠结肠炎（NEC）是孕32周前出生或出生体重低于1500克的早产儿发病和死亡的主要原因。在本文中，我们综述了与NEC相关的血液学异常。
方法
使用数据库PubMed、EMBASE和Scopus以及在儿科学术协会年会上发表的摘要电子存档进行文献检索。
结果
血小板减少、弥散性血管内凝血、中性粒细胞计数增加或减少以及溶血性贫血在NEC中很常见。
结论
NEC与多种血液学异常相关，这些异常可能在肠道黏膜损伤的发病机制中起直接或间接作用，也可能携带重要的预后信息。
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