Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA, USA.
Aliment Pharmacol Ther. 2012 Oct;36(8):772-81. doi: 10.1111/apt.12038. Epub 2012 Sep 8.
High intensity exercise improves metabolic status and may potentially mobilise hepatic fat.
To assess the level of physical activity (PA) of subjects with non-alcoholic fatty liver disease (NAFLD).
Data were obtained from NHANES (2003-2006). Activity counts obtained from accelerometer readings (ActiGraph, Fort Walton Beach, FL), from 7 consecutive days quantified total PA and time spent engaged in different levels of activity. All measures were counts/minutes/day: (sedentary <100; light 100-0027; moderate, 2020-5999 and vigorous, 6000+). NAFLD was defined as a fatty liver index >60 (FLI) in the absence of other chronic liver disease. Subjects with NAFLD were compared to controls using stratum-specific Chi-squared and t-tests. Simple linear regression analyses (with Taylor series linearised variance estimation and weighting) were used to determine the association between PA levels and NAFLD. P-values <0.05 were considered significant. Statistical analyses were conducted using sudaan version 10.1 and sas version 9.1.
We included 3056 participants. NAFLD patients were older, had higher BMI, larger waist circumference, higher sum of skinfolds, more likely to have insulin resistance (HOMA > 3.0) and type-2 diabetes (all P-values <0.01). Average PA for NAFLD subjects was about 28.7 counts/minute/day less than controls (P < 0.01). Furthermore, NAFLD subjects spent less time participating in activity at any level (P < 0.01). Subjects with NAFLD and DM were in the lowest quartile of average PA as well as moderate-vigorous PA (P < 0.01).
Data from this study show that non-alcoholic fatty liver disease patients have low level of physical activity and, when they have diabetes mellitus, they perform at the lowest quartile of physical activity and moderate-vigorous physical activity.
高强度运动可改善代谢状态，并可能动员肝内脂肪。
评估非酒精性脂肪肝 (NAFLD) 患者的体力活动 (PA) 水平。
数据来自 NHANES（2003-2006 年）。使用加速度计读数（ActiGraph，佛罗里达州沃尔顿堡海滩）获得的活动计数，在 7 天的连续时间内量化了总 PA 和从事不同活动水平的时间。所有指标均为计数/分钟/天：（久坐<100；轻度 100-0027；中度 2020-5999；剧烈 6000+）。在没有其他慢性肝病的情况下，NAFLD 定义为脂肪肝指数>60（FLI）。使用分层特定的卡方检验和 t 检验将 NAFLD 患者与对照组进行比较。使用简单线性回归分析（使用泰勒级数线性化方差估计和加权）来确定 PA 水平与 NAFLD 之间的关联。P 值<0.05 被认为具有统计学意义。统计分析使用 sudaan 版本 10.1 和 sas 版本 9.1 进行。
我们纳入了 3056 名参与者。NAFLD 患者年龄更大，BMI 更高，腰围更大，皮褶厚度总和更高，胰岛素抵抗（HOMA>3.0）和 2 型糖尿病的可能性更高（所有 P 值均<0.01）。NAFLD 患者的平均 PA 比对照组少约 28.7 计数/分钟/天（P<0.01）。此外，NAFLD 患者在任何活动水平上的参与时间都较少（P<0.01）。NAFLD 合并糖尿病的患者的平均 PA 和中高强度 PA 也处于最低四分位数（P<0.01）。
本研究数据表明，非酒精性脂肪肝患者的体力活动水平较低，当他们患有糖尿病时，他们的体力活动和中高强度体力活动处于最低四分位数。
