幽门螺杆菌感染的炎症、免疫与疫苗
Inflammation, immunity, and vaccines for Helicobacter pylori infection.
机构信息
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.
出版信息
Helicobacter. 2012 Sep;17 Suppl 1(Suppl 1):16-21. doi: 10.1111/j.1523-5378.2012.00977.x.
Abstract
The immune response to Helicobacter pylori is a multifaceted group of mechanisms involving responses that are both protective and damaging to the host. The innate and the adaptive immune responses lead to damaging inflammatory responses, but these responses may fail, allowing for persistence of many infections. Thus, developing new therapeutics and effective vaccines against H. pylori has proven to be arduous. In this manuscript, we will examine the advances in knowledge made in the past year in understanding the host immune response to H. pylori and the progress toward developing a vaccine.
摘要
针对幽门螺杆菌的免疫反应是一组多方面的机制，涉及对宿主具有保护和损害作用的反应。先天免疫和适应性免疫反应导致破坏性炎症反应，但这些反应可能会失败，从而导致许多感染持续存在。因此，针对 H. pylori 开发新的治疗方法和有效的疫苗已被证明是艰巨的。在本文中，我们将研究过去一年在理解宿主对 H. pylori 的免疫反应以及朝着开发疫苗方面取得的进展方面的知识进展。
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