Hagymási Krisztina, Tulassay Zsolt
Krisztina Hagymási, Zsolt Tulassay, 2 Department of Internal Medicine, Semmelweis University, H-1088 Budapest, Hungary.
World J Gastroenterol. 2014 Jun 7;20(21):6386-99. doi: 10.3748/wjg.v20.i21.6386.
Helicobacter pylori (H. pylori) infects more than half of the world's human population, but only 1% to 3% of infected people consequently develop gastric adenocarcinomas. The clinical outcome of the infection is determined by host genetic predisposition, bacterial virulence factors, and environmental factors. The association between H. pylori infection and chronic active gastritis, peptic ulcer disease, gastric cell carcinoma, and B cell mucosa-associated lymphoid tissue lymphoma has been well established. With the exception of unexplained iron deficiency anemia and idiopathic thrombocytopenic purpura, H. pylori infection has no proven role in extraintestinal diseases. On the other hand, there is data showing that H. pylori infection could be beneficial for some human diseases. The unpredictability of the long-term consequences of H. pylori infection and the economic challenge in eradicating it is why identification of high-risk individuals is crucial.
幽门螺杆菌（H. pylori）感染了全球一半以上的人口，但只有1%至3%的感染者最终会发展为胃腺癌。感染的临床结果由宿主遗传易感性、细菌毒力因子和环境因素决定。幽门螺杆菌感染与慢性活动性胃炎、消化性溃疡病、胃细胞癌和B细胞黏膜相关淋巴组织淋巴瘤之间的关联已得到充分证实。除了不明原因的缺铁性贫血和特发性血小板减少性紫癜外，幽门螺杆菌感染在肠道外疾病中没有已证实的作用。另一方面，有数据表明幽门螺杆菌感染可能对某些人类疾病有益。幽门螺杆菌感染长期后果的不可预测性以及根除它所面临的经济挑战，正是识别高危个体至关重要的原因。
