School of Nursing, Midwifery and Paramedicine, Australian Catholic University, Dickson, PO BOX 256, ACT, Australia.
Antimicrob Resist Infect Control. 2012 May 30;1(1):20. doi: 10.1186/2047-2994-1-20.
Clostridium difficile infection (CDI) is a common cause of diarrhoea in hospitalised patients. Around the world, the incidence and severity of CDI appears to be increasing, particularly in the northern hemisphere. The purpose of this integrative review was to investigate and describe mortality in hospitalised patients with CDI.
A search of the literature between 1 January 2005 and 30 April 2011 focusing on mortality and CDI in hospitalised patients was conducted using electronic databases. Papers were reviewed and analysed individually and themes were combined using integrative methods.
All cause mortality at 30 days varied from 9% to 38%. Three studies report attributable mortality at 30 days, varying from 5.7% to 6.9%. In hospital mortality ranged from 8% to 37.2%
All cause 30 day mortality appeared to be high, with 15 studies indicating a mortality of 15% or greater. Findings support the notion that CDI is a serious infection and measures to prevent and control CDI are needed. Future studies investigating the mortality of CDI in settings outside of Europe and North America are needed. Similarly, future studies should include data on patient co-morbidities.
艰难梭菌感染（CDI）是住院患者腹泻的常见原因。在全球范围内，CDI 的发病率和严重程度似乎都在增加，尤其是在北半球。本次综合回顾的目的是调查和描述 CDI 住院患者的死亡率。
在 2005 年 1 月 1 日至 2011 年 4 月 30 日期间，使用电子数据库对关注住院患者死亡率和 CDI 的文献进行了检索。对论文进行了单独审查和分析，并使用综合方法合并了主题。
30 天全因死亡率从 9%到 38%不等。有三项研究报告了 30 天归因死亡率，从 5.7%到 6.9%不等。住院死亡率从 8%到 37.2%不等。
30 天全因死亡率似乎很高，有 15 项研究表明死亡率为 15%或更高。研究结果支持 CDI 是一种严重感染的观点，需要采取措施预防和控制 CDI。需要在欧洲和北美以外的环境中开展研究 CDI 死亡率的未来研究。同样，未来的研究应该包括患者合并症的数据。
