修复足细胞损伤：Wnt、Notch 与肾小球硬化。
Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis.
机构信息
Department of Medicine, Division of Nephrology, University of Teikyo, Tokyo, Japan.
出版信息
Semin Nephrol. 2012 Jul;32(4):350-6. doi: 10.1016/j.semnephrol.2012.06.006.
Abstract
Wnt/Ctnnb1 and Notch signaling play key roles in kidney development and epithelial cell specification. Recent reports have suggested that these pathways are reactivated in response to injury and in different disease conditions. Studies using genetically modified animal models showed that sustained activation of Notch and Wnt signaling in podocytes are causally related to albuminuria and glomerulosclerosis development. Here, we discuss the role and regulation of Wnt/Ctnnb1 and Notch signaling in podocytes.
摘要
Wnt/Ctnnb1 和 Notch 信号通路在肾脏发育和上皮细胞特化中发挥关键作用。最近的研究报告表明，这些通路在受到损伤和不同疾病状态下会被重新激活。使用基因修饰动物模型的研究表明，足细胞中 Notch 和 Wnt 信号的持续激活与蛋白尿和肾小球硬化的发展有因果关系。本文讨论了 Wnt/Ctnnb1 和 Notch 信号通路在足细胞中的作用和调节。
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