State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
J Colloid Interface Sci. 2012 Dec 1;387(1):115-22. doi: 10.1016/j.jcis.2012.07.059. Epub 2012 Aug 8.
In this paper, 1,4-bi(phenylalanine-diglycol)-benzene (PDB) based Low-Molecular-Weight-Gelator (LMWG) hydrogels are modified using hydrophilic polysaccharide (sodium alginate). A set of techniques including Fourier transform infrared (FT-IR) spectroscopy, (1)H Nuclear Magnetic Resonance ((1)H NMR), X-ray powder diffraction (XRD), Ultraviolet-Visible (UV-Vis), and circular dichroism (CD) had confirmed a β-turn arrangement of PDB gelators and a semi-interpenetrating network (semi-IPN), which was formed through hydrogen bonds between LMWG fibers and polysaccharide chains. The evaluation of physicochemical properties of hydrogels indicates that gelator-polysaccharide hybrid hydrogels possess better mechanical and water retention properties than LMWG hydrogels. The release study of dyes (model drug) from both LMWG and hybrid hydrogels was carried out. Compared with PDB based hydrogels, hybrid hydrogels show a selective and controllable release property for certain dyes. The results suggest LMWG-polysaccharide hybrid gels may find potential applications as promising drug delivery vehicles for drug molecules.
本文中，基于 1,4-双（苯丙氨酸-二甘醇）-苯（PDB）的低分子量凝胶剂（LMWG）水凝胶通过亲水性多糖（海藻酸钠）进行改性。一系列技术，包括傅里叶变换红外（FT-IR）光谱、（1）H 核磁共振（1H NMR）、X 射线粉末衍射（XRD）、紫外可见（UV-Vis）和圆二色性（CD），证实了 PDB 凝胶剂的β-转角排列和半互穿网络（半 IPN），这是通过 LMWG 纤维和多糖链之间的氢键形成的。水凝胶的物理化学性质评估表明，凝胶剂-多糖杂化水凝胶具有比 LMWG 水凝胶更好的机械性能和保水性能。对染料（模型药物）从 LMWG 和杂化水凝胶中的释放研究表明，与基于 PDB 的水凝胶相比，杂化水凝胶对某些染料具有选择性和可控的释放性能。这些结果表明，LMWG-多糖杂化凝胶可能作为有前途的药物输送载体，用于药物分子。
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