Department of Thoracic Oncosurgery, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
FEBS Lett. 2012 Sep 21;586(19):3508-21. doi: 10.1016/j.febslet.2012.08.007. Epub 2012 Aug 14.
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that regulate gene expression at the post-transcriptional levels. Recent studies show that miRNAs may function as oncogenes or tumor suppressor genes. In this study, we demonstrated that miR-518b was down-regulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with metastasis and survival. miR-518b suppressed the proliferation by inducing apoptosis and repressed the invasion in ESCC cells, but had no effect on the cell cycle. Furthermore, Rap1b was revealed to be directly regulated by miR-518b. These findings indicate that miR-518b may function as a tumor suppressor by targeting Rap1b in the development of ESCC and has important clinical and prognostic value.
微小 RNA（miRNAs）是一类小的非编码 RNA，可在转录后水平调节基因表达。最近的研究表明，miRNAs 可能作为癌基因或肿瘤抑制基因发挥作用。在这项研究中，我们证明 miR-518b 在食管鳞状细胞癌（ESCC）组织中下调，并与转移和生存相关。miR-518b 通过诱导细胞凋亡抑制 ESCC 细胞的增殖，并抑制其侵袭，但对细胞周期没有影响。此外，发现 Rap1b 被 miR-518b 直接调控。这些发现表明，miR-518b 可能通过靶向 ESCC 中 Rap1b 发挥肿瘤抑制作用，具有重要的临床和预后价值。
