Nottingham Biomedical Research Unit, Department of Respiratory Medicine, City Hospital, Nottingham NG5 1PB, UK.
J Cyst Fibros. 2013 May;12(3):284-9. doi: 10.1016/j.jcf.2012.08.008. Epub 2012 Sep 5.
Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.
Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.
Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171ml (95% confidence intervals CI: +116 to +227ml) in males and 90ml (95% CI: +46 to +133ml) in females. Compared to the reference group of 20-24.9kg/m(2), those with a BMI<20kg/m(2) had lower FEV1 with values of -642ml (95%CI: -784 to -500ml) for males and -468ml (95%CI: -564 to -372ml) for females.
Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.
体貌差异可能解释了一些囊性纤维化（CF）患者之间肺功能的差异。我们验证了以下假设，即瘦肌肉量和肥胖的衡量指标与 CF 患者的肺功能独立相关。
采用英国 CF 注册数据的横断面研究设计，纳入 2096 例临床稳定的成年人。
血清肌酐和 BMI 与 FEV1 和 FVC 呈正相关且独立相关。血清肌酐增加一个标准差与男性 FEV1 增加 171ml（95%置信区间 CI：+116 至 +227ml）和女性 FEV1 增加 90ml（95%CI：+46 至 +133ml）相关。与 BMI 为 20-24.9kg/m2 的参考组相比，BMI<20kg/m2 的男性和女性的 FEV1 分别低 642ml（95%CI：-784 至 -500ml）和 468ml（95%CI：-564 至 -372ml）。
需要进行前瞻性研究和对照试验，以确定这些关联是否具有改变疾病进展的治疗潜力。
