Chatterjee S N, Jordan G W
Transplantation. 1979 Dec;28(6):457-60.
To determine the incidence and symptomatology of cytomegalovirus (CMV) infection in renal transplant recipients, we followed 40 patients prospectively for 5 to 24 months after operation. As judged by the serological change and virus isolation from blood and/or urine, the infection rate for the entire group was 82% (33 of 40 patients). Two types of infection were recognized: primary infection that occurred in 3 patients, and reactivation infection that occurred in 30 patients. Twenty-one patients were asymptomatic and 12 were mildly symptomatic. Four had mild hepatic dysfunction; two had the CMV mononucleosis syndrome associated with mild to moderate deterioration of renal function. Two patients had hyperglycemia. One patient who reached a CMV antibody titer of 1:32,768 was totally asymptomatic other than fever of short duration. CMV-induced pneumonitis or retinitis was not noted, and there was no mortality from CMV infection in our patients. Factors which may be associated with the absence of severe manifestations of active CMV infection in these patients are discussed.
为了确定肾移植受者巨细胞病毒（CMV）感染的发生率和症状，我们对40例患者术后进行了5至24个月的前瞻性随访。根据血清学变化以及从血液和/或尿液中分离出病毒判断，整个组的感染率为82%（40例患者中的33例）。确认有两种感染类型：3例发生原发性感染，30例发生再激活感染。21例患者无症状，12例有轻微症状。4例有轻度肝功能障碍；2例患有与肾功能轻度至中度恶化相关的CMV单核细胞增多症综合征。2例患者有高血糖症。1例CMV抗体滴度达到1:32,768的患者除了有短时间发热外完全无症状。未发现CMV引起的肺炎或视网膜炎，我们的患者中也没有因CMV感染导致的死亡。本文讨论了可能与这些患者未出现活动性CMV感染严重表现相关的因素。
