Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
Fertil Steril. 2012 Nov;98(5):1152-6. doi: 10.1016/j.fertnstert.2012.07.1141. Epub 2012 Sep 6.
To identify patient, cycle, and retrieval characteristics associated with embryo implantation and live birth in patients undergoing single embryo transfer (SET).
Analysis of prospectively collected IVF database.
Academic IVF program.
PATIENT(S): All patient cycles meeting criteria for SET between June 2004 and September 2010.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Clinical pregnancy and live birth.
RESULT(S): Single embryo transfer was performed in 438 cycles, resulting in a clinical pregnancy rate of 76.2% and a live birth rate of 66.8% per transfer. Clinical pregnancy was associated with younger female age, ≥ 58% mature (metaphase II) oocytes at the time of retrieval, and increasing blastocyst expansion. Ongoing pregnancy was associated with younger female age and more advanced blastocysts. A diagnosis of uterine factor was negatively associated with live birth.
CONCLUSION(S): Even in a favorable prognosis population, younger female age is associated with clinical pregnancy and live birth. Although all patients underwent blastocyst transfer, expanded and hatching blastocysts were strongly associated with pregnancy and live birth. A diagnosis of uterine factor was the only infertility diagnosis found to affect live birth after SET. Obesity did not negatively affect SET outcome. These findings may assist physicians in determining the best candidates for SET.
确定与接受单胚胎移植（SET）的患者的胚胎着床和活产相关的患者、周期和检索特征。
对前瞻性收集的 IVF 数据库进行分析。
学术性 IVF 计划。
2004 年 6 月至 2010 年 9 月期间符合 SET 标准的所有患者周期。
无。
临床妊娠和活产。
438 个周期进行了单胚胎移植，每个移植的临床妊娠率为 76.2%，活产率为 66.8%。临床妊娠与女性年龄较小、取卵时≥58%成熟（MII）卵母细胞以及囊胚扩张增加有关。持续妊娠与女性年龄较小和更先进的囊胚有关。子宫因素的诊断与活产呈负相关。
即使在预后良好的人群中，女性年龄较小也与临床妊娠和活产有关。尽管所有患者均进行了囊胚移植，但扩张和孵化的囊胚与妊娠和活产密切相关。子宫因素的诊断是 SET 后唯一影响活产的不孕诊断。肥胖并未对 SET 结果产生负面影响。这些发现可以帮助医生确定最适合 SET 的患者。
