Center for Cancer Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai 200031, PR China.
Exp Cell Res. 2013 Jan 15;319(2):152-9. doi: 10.1016/j.yexcr.2012.08.005. Epub 2012 Aug 31.
Eph receptors and their membrane-bound ephrin ligands are intimately involved in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis. In recent years, a growing number of studies revealed their participation in the development of various cancers. In this review, we concentrate on their involvement in lung cancer. In this context, we summarize their aberrant expressions, their pro- or anti-oncogenic effects as well as related mechanisms, and their potential as drug targets in lung cancer.
Eph 受体及其膜结合的 Ephrin 配体在正常胚胎发生过程中胚胎模式形成、神经元靶向和血管发育中密切相关。近年来，越来越多的研究表明它们参与了各种癌症的发展。在这篇综述中，我们集中讨论它们在肺癌中的作用。在这方面，我们总结了它们的异常表达、它们的致癌或抗癌作用及其相关机制，以及它们作为肺癌药物靶点的潜力。
