Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Germany.
Biol Psychol. 2012 Dec;91(3):329-33. doi: 10.1016/j.biopsycho.2012.08.009. Epub 2012 Aug 30.
The hyperarousal model of primary insomnia suggests that a deficit of attenuating arousal during sleep might cause the experience of non-restorative sleep. In the current study, we examined EEG spectral power values for standard frequency bands as indices of cortical arousal and sleep protecting mechanisms during sleep in 25 patients with primary insomnia and 29 good sleeper controls. Patients with primary insomnia demonstrated significantly elevated spectral power values in the EEG beta and sigma frequency band during NREM stage 2 sleep. No differences were observed in other frequency bands or during REM sleep. Based on prior studies suggesting that EEG beta activity represents a marker of cortical arousal and EEG sleep spindle (sigma) activity is an index of sleep protective mechanisms, our findings may provide further evidence for the concept that a simultaneous activation of wake-promoting and sleep-protecting neural activity patterns contributes to the experience of non-restorative sleep in primary insomnia.
原发性失眠的过度唤醒模型表明，睡眠期间唤醒的衰减不足可能导致非恢复性睡眠的体验。在当前的研究中，我们检查了原发性失眠患者 25 例和良好睡眠者对照 29 例的 EEG 频带的光谱功率值，以作为睡眠期间皮质唤醒和睡眠保护机制的指标。原发性失眠患者在 NREM 睡眠阶段 2 时，脑电图β和σ频带的光谱功率值显著升高。在其他频带或 REM 睡眠期间未观察到差异。基于先前的研究表明，脑电图β活动代表皮质唤醒的标志物，而脑电图睡眠纺锤（σ）活动是睡眠保护机制的指标，我们的发现可能为以下概念提供进一步证据，即促进觉醒和保护睡眠的神经活动模式的同时激活有助于原发性失眠的非恢复性睡眠体验。
