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Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity.性别二态性：衰老肾脏、一氧化氮缺乏的参与和血管紧张素 II 过度活跃。
J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1365-72. doi: 10.1093/gerona/gls171. Epub 2012 Sep 7.
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Sexual dimorphism, the aging kidney, and involvement of nitric oxide deficiency.性别二态性、衰老的肾脏和一氧化氮缺乏的参与。
Semin Nephrol. 2009 Nov;29(6):569-78. doi: 10.1016/j.semnephrol.2009.07.003.
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Sexual dimorphism in the aging kidney: differences in the nitric oxide system.衰老肾脏中的性别二态性：一氧化氮系统的差异。
Nat Rev Nephrol. 2009 Jul;5(7):384-96. doi: 10.1038/nrneph.2009.90. Epub 2009 Jun 2.
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Sexual dimorphism of the aging kidney: role of nitric oxide deficiency.衰老肾脏的性别二态性：一氧化氮缺乏的作用。
Physiology (Bethesda). 2008 Jun;23:142-50. doi: 10.1152/physiol.00001.2008.
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Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system.衰老肾脏中肾血流动力学和结构的变化；性别差异与一氧化氮系统
Exp Gerontol. 2005 Apr;40(4):271-8. doi: 10.1016/j.exger.2005.01.008.
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Sexual dimorphism in development of kidney damage in aging Fischer-344 rats.衰老的Fischer-344大鼠肾损伤发育中的性别二态性。
Gend Med. 2012 Aug;9(4):219-31. doi: 10.1016/j.genm.2012.06.003. Epub 2012 Jul 20.
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The aging glomerulus.衰老的肾小球
Semin Nephrol. 1996 Jul;16(4):265-76.
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Gender-dependent effects of aging on the kidney.性别对肾脏衰老的影响。
Braz J Med Biol Res. 2011 Sep;44(9):905-13. doi: 10.1590/s0100-879x2011007500101. Epub 2011 Aug 19.
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Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.神经退行性疾病：性别、激素和氧化应激的作用。
Endocrinology. 2021 Nov 1;162(11). doi: 10.1210/endocr/bqab185.
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Sexual dimorphism in the aging kidney: Effects on injury and nitric oxide system.衰老肾脏中的性别二态性：对损伤和一氧化氮系统的影响。
Kidney Int. 2003 Mar;63(3):1021-6. doi: 10.1046/j.1523-1755.2003.00830.x.
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Oxidative stress and senescence in aging kidneys: the protective role of SIRT1.衰老肾脏中的氧化应激与衰老：SIRT1的保护作用
EXCLI J. 2024 Aug 27;23:1030-1067. doi: 10.17179/excli2024-7519. eCollection 2024.
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Mechanisms and consequences of sex differences in immune responses.免疫反应中性别差异的机制和后果。
Nat Rev Nephrol. 2024 Jan;20(1):37-55. doi: 10.1038/s41581-023-00787-w. Epub 2023 Nov 22.
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Sexual dimorphic response to rituximab treatment: A longitudinal observational study in a large cohort of patients with primary membranous nephropathy and persistent nephrotic syndrome.利妥昔单抗治疗的性别差异反应：一项针对大量原发性膜性肾病和持续性肾病综合征患者队列的纵向观察研究。
Front Pharmacol. 2022 Sep 2;13:958136. doi: 10.3389/fphar.2022.958136. eCollection 2022.
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Gender-biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females.香烟烟雾暴露后雄性小鼠肾脏损伤的性别偏向：绝经前女性受保护作用更强。
Physiol Rep. 2020 Jan;8(2):e14339. doi: 10.14814/phy2.14339.
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Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly.细胞外基质在心脏肾纤维化中的作用：老年人心血管疾病和慢性肾脏病的潜在治疗靶点。
Pharmacol Ther. 2019 Jan;193:99-120. doi: 10.1016/j.pharmthera.2018.08.014. Epub 2018 Aug 25.
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Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease.慢性肾脏病的流行病学和结局中的性别差异。
Nat Rev Nephrol. 2018 Mar;14(3):151-164. doi: 10.1038/nrneph.2017.181. Epub 2018 Jan 22.
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Consequences of advanced aging on renal function in chronic hyperandrogenemic female rat model: implications for aging women with polycystic ovary syndrome.慢性高雄激素血症雌性大鼠模型中衰老对肾功能的影响：对患有多囊卵巢综合征的老年女性的启示
Physiol Rep. 2017 Nov;5(20). doi: 10.14814/phy2.13461.
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Sex- and age-related differences in arterial pressure and albuminuria in mice.小鼠动脉血压和蛋白尿的性别及年龄相关差异。
Biol Sex Differ. 2016 Nov 14;7:57. doi: 10.1186/s13293-016-0110-x. eCollection 2016.
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Aging-associated renal disease in mice is fructokinase dependent.小鼠衰老相关的肾脏疾病依赖果糖激酶。
Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F722-F730. doi: 10.1152/ajprenal.00306.2016. Epub 2016 Jul 27.
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Sex Differences in Renal Proximal Tubular Cell Homeostasis.肾近端小管细胞内环境稳定中的性别差异
J Am Soc Nephrol. 2016 Oct;27(10):3051-3062. doi: 10.1681/ASN.2015080886. Epub 2016 Apr 28.
本文引用的文献
1
Sex differences in primary hypertension.原发性高血压的性别差异。
Biol Sex Differ. 2012 Mar 14;3(1):7. doi: 10.1186/2042-6410-3-7.
2
Low birth weight and end-stage renal disease: demographic analysis by region in Japan.低出生体重与终末期肾病：日本按地区的人口统计学分析。
Clin Exp Nephrol. 2012 Aug;16(4):596-603. doi: 10.1007/s10157-012-0600-z.
3
Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen.G蛋白偶联膜受体GPR30有助于雌激素发挥心血管作用的证据。
Gend Med. 2011 Dec;8(6):343-54. doi: 10.1016/j.genm.2011.10.004.
4
Estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo.足细胞中雌激素受体 α 的表达介导了体内外细胞凋亡的保护作用。
PLoS One. 2011;6(11):e27457. doi: 10.1371/journal.pone.0027457. Epub 2011 Nov 11.
5
Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.12 周的跑步机运动不能改变 Fisher 344 雄性大鼠的年龄相关性慢性肾脏病。
J Physiol. 2011 Dec 15;589(Pt 24):6129-38. doi: 10.1113/jphysiol.2011.214569. Epub 2011 Oct 3.
6
Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging.使用磁共振成像技术无创评估肾脏缺氧和纤维化。
J Am Soc Nephrol. 2011 Aug;22(8):1429-34. doi: 10.1681/ASN.2010111143. Epub 2011 Jul 14.
7
Human nephron number: implications for health and disease.人类肾单位数量：对健康和疾病的影响。
Pediatr Nephrol. 2011 Sep;26(9):1529-33. doi: 10.1007/s00467-011-1843-8. Epub 2011 May 22.
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Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension.肾内血管紧张素 II 及其在慢性高血压发病机制中的作用。
Curr Opin Pharmacol. 2011 Apr;11(2):180-6. doi: 10.1016/j.coph.2011.01.009. Epub 2011 Feb 19.
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Prenatal programming-effects on blood pressure and renal function.产前编程对血压和肾功能的影响。
Nat Rev Nephrol. 2011 Mar;7(3):137-44. doi: 10.1038/nrneph.2011.1. Epub 2011 Feb 1.
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Cell signaling of angiotensin II on vascular tone: novel mechanisms.血管紧张素 II 对血管张力的细胞信号转导：新机制。
Curr Hypertens Rep. 2011 Apr;13(2):122-8. doi: 10.1007/s11906-011-0187-x.
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