Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Science, Shandong Normal University, Jinan, China.
Exp Gerontol. 2012 Dec;47(12):940-9. doi: 10.1016/j.exger.2012.08.009. Epub 2012 Aug 31.
Aging research was hindered because of the long lifespan of available vertebrates. Annual fishes of Nothobranchius have become a new model organism for aging studies. Resveratrol, a natural plant-derived chemical, prolongs lifespan in many animals. Here we used the wild strain of N. guentheri, which has the mean lifespan of 12months, to detect the effects of resveratrol on the longevity, cognitive ability and aging-related histological markers. Our results showed that the pharmaceutical treatment of resveratrol prolonged the lifespan of N. guentheri but did not affect their body size. Three behavioral assays for cognitive ability and locomotor activity demonstrated that the resveratrol-treated fish exhibited the higher rate of performances than the fish in the control group. Further data indicated that resveratrol not only had the property of protecting N. guentheri from neurodegeneration, but retarded the aging-related histological markers in lipofuscin formation and in the expression of senescence-associated beta-galactosidase activity.
衰老研究受到限于可供研究的脊椎动物的长寿命。Nothobranchius 属的一年生鱼类已成为衰老研究的新模型生物。白藜芦醇是一种天然植物衍生的化学物质，能延长许多动物的寿命。在这里，我们使用平均寿命为 12 个月的野生 N. guentheri 种群来检测白藜芦醇对长寿、认知能力和与衰老相关的组织学标志物的影响。我们的结果表明，白藜芦醇的药物治疗延长了 N. guentheri 的寿命，但不影响其体型。三种用于认知能力和运动活性的行为检测表明，经白藜芦醇处理的鱼比对照组的鱼表现出更高的性能。进一步的数据表明，白藜芦醇不仅具有保护 N. guentheri 免受神经退行性变的特性，而且还延缓了脂褐素形成和衰老相关的β-半乳糖苷酶活性表达的组织学标志物的发展。
