免疫调节中的生发中心激酶。
Germinal center kinases in immune regulation.
机构信息
Department of Trauma and Orthopaedics, General Hospital of Jinan Military Region, Jinan, China.
出版信息
Cell Mol Immunol. 2012 Nov;9(6):439-45. doi: 10.1038/cmi.2012.30. Epub 2012 Sep 10.
Abstract
Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.
摘要
生殖中心激酶（GCKs）参与了多种信号通路，这些通路对于调节细胞功能（包括细胞凋亡、细胞增殖、极性和迁移）是必需的。最近的研究表明，GCKs 是适应性和先天免疫调节的参与者。然而，GCKs 的差异激活和调节机制，以及上游和下游信号分子，仍有待充分定义。目前尚不清楚 GCKs 是否以及如何与现有信号通路相互作用。本综述强调了与免疫系统相关的 GCKs 研究进展。
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