Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry of the Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Cell Biochem Funct. 2013 Mar;31(2):136-51. doi: 10.1002/cbf.2868. Epub 2012 Sep 7.
The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non-enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L-NAME and Exercise L-NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L-NAME-treated group was reverted by physical training in serum from the Exercise L-NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L-NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L-NAME group when compared with the L-NAME group (P < 0·05). There was a decrease in the non-protein thiols (NPSH) levels in the L-NAME-treated group when compared with the normotensive groups (P < 0·05). In the Exercise L-NAME group, there was an increase in NPSH levels when compared with the L-NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L-NAME group were reverted to levels close to normal by exercise in the Exercise L-NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L-NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension.
本研究探讨了 6 周游泳训练对血压、一氧化氮（NO）水平以及氧化应激参数（如蛋白质和脂质氧化、抗氧化酶活性和内源性非酶抗氧化剂含量）的影响，以及对 Nω-硝基-L-精氨酸甲酯盐酸盐（L-NAME）诱导的高血压大鼠的血清生化参数（胆固醇、甘油三酯、尿素和肌酐）的影响。动物分为四组（n = 10）：对照组、运动组、L-NAME 组和运动 L-NAME 组。结果表明，运动可防止高血压大鼠的 NO 水平降低（P < 0·05）。与正常血压组相比，运动训练可使 L-NAME 组血清中观察到的蛋白质和脂质氧化增加得到逆转（P < 0·05）。与正常血压组相比，L-NAME 组的过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性降低（P < 0·05）。与 L-NAME 组相比，运动 L-NAME 组的 CAT 和 SOD 活性显著增加（P < 0·05）。与正常血压组相比，L-NAME 组的非蛋白巯基（NPSH）水平降低（P < 0·05）。与 L-NAME 组相比，运动 L-NAME 组的 NPSH 水平升高（P < 0·05）。与 L-NAME 组相比，运动 L-NAME 组的血清胆固醇、甘油三酯、尿素和肌酐水平升高，接近正常（P < 0·05）。运动训练具有降压作用，可降低运动 L-NAME 组的血压（P < 0·05）。这些发现表明，运动训练可能对高血压引起的氧化损伤和肾损伤具有保护作用。
