Research Division of Microbial Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.
Appl Environ Microbiol. 2012 Nov;78(22):8161-3. doi: 10.1128/AEM.02356-12. Epub 2012 Sep 7.
Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower in HAA1-overexpressing cells than in the wild-type cells.
Haa1 是酿酒酵母适应弱酸所必需的转录激活因子。在这里,我们发现组成型过表达 HAA1 的菌株获得了更高水平的乙酸耐受性。在乙酸胁迫条件下,HAA1 过表达细胞内的乙酸水平明显低于野生型细胞。