三种来自斐济海洋海绵属 Hippospongia 的生物活性倍半萜醌类化合物。

Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia.

机构信息

a Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific , Suva , Fiji Islands.

出版信息

Nat Prod Res. 2013;27(16):1488-91. doi: 10.1080/14786419.2012.722086. Epub 2012 Sep 10.

DOI:10.1080/14786419.2012.722086

PMID:22963320

Abstract

A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine sponge Hippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first time in this study from the sponge of the genus Hippospongia. Compound 1 displayed potent cytotoxic activity and showed antibacterial activity against methicillin-resistant Staphylococcus aureus, wild type S. aureus and vancomycin-resistant Enterococcus faecium and displayed antifungal activity against amphotericin-resistant Candida albicans while compounds 2 and 3 showed moderate cytotoxic activity. However, compound 1 did not show appreciable antifungal activity against wild type C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia or Sordaria sp.

摘要

从斐济海洋海绵 Hippospongia sp. 中分离得到一种倍半萜醌类化合物 epi-ilimaquinone (1)，以及两种倍半萜烯氨基醌类化合物 smenospongine (2) 和 glycinylilimaquinone (3)。通过光谱分析确定了这些化合物的结构。在本研究中，化合物 1 和 3 首次从 Hippospongia 属海绵中报道。化合物 1 表现出很强的细胞毒性，并显示出对耐甲氧西林金黄色葡萄球菌、野生型金黄色葡萄球菌和万古霉素耐药粪肠球菌的抗菌活性，同时对两性霉素 B 耐药白念珠菌具有抗真菌活性，而化合物 2 和 3 则表现出中等的细胞毒性活性。然而，化合物 1 对野生型白念珠菌、新型隐球菌、黑曲霉、青霉、根霉或 Sordaria sp. 没有明显的抗真菌活性。