来自海洋海绵 Hyrtios sp. 的倍半萜-二氢醌衍生物 Puupehanol。
Puupehanol, a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp.
机构信息
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
出版信息
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6140-3. doi: 10.1016/j.bmcl.2009.09.015. Epub 2009 Sep 11.
Abstract
Puupehanol (1), a new sesquiterpene-dihydroquinone derivative, was isolated from the marine sponge Hyrtios sp., along with the known compounds puupehenone (2) and chloropuupehenone (3) that are responsible for the antifungal activity observed in the extract. The structure of 1 was established as (20R,21R)-21-hydroxy-20,21-dihydropuupehenone by extensive spectroscopic and computational methods. Compound 2 exhibited potent activity against Cryptococcus neoformans and Candida krusei with MFCs of 1.25 and 2.50 microg/mL, respectively.
摘要
普乌潘醇（1），一种新的倍半萜二氢醌衍生物，从海洋海绵 Hyrtios sp. 中分离出来，同时还分离出了已知的化合物普乌潘酮（2）和氯普乌潘酮（3），它们是提取物中观察到的抗真菌活性的原因。通过广泛的光谱和计算方法，确定 1 的结构为（20R,21R）-21-羟基-20,21-二氢普乌潘酮。化合物 2 对新型隐球菌和克柔念珠菌表现出很强的活性，MFC 分别为 1.25 和 2.50 μg/mL。
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