2013 年 9 月 12 日至 15 日，意大利佛罗伦萨 ISN 前沿会议报告：干细胞与肾脏再生。

Report on ISN Forefronts, Florence, Italy, 12-15 September 2013: Stem cells and kidney regeneration.

机构信息

1] Department of Biomedical, Experimental and Clinical Sciences, Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Florence, Italy [2] Pediatric Nephrology Unit, Meyer Children's Hospital, Florence, Italy.

1] Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

出版信息

Kidney Int. 2014 Jul;86(1):23-7. doi: 10.1038/ki.2014.32. Epub 2014 Jun 4.

DOI:10.1038/ki.2014.32

PMID:24897031

Abstract

In recent years it has become clear that most organs and tissues, including kidney, contain resident stem/progenitor cells. Stem cells are undifferentiated, long-lived cells that are unique in their ability to produce differentiated daughter cells and to retain their stem cell identity by self-renewal. A primary goal of this meeting was to review the current understanding of kidney stem cells and mechanisms of kidney regeneration in both lower vertebrates and mammals. Presenters covered a broad range of topics including stem cell quiescence, epigenetics, transcriptional control circuits, dedifferentiation, pluripotent stem cells, renal progenitors, and novel imaging approaches in kidney regeneration. By the end of this highly interactive conference it was clear we are entering into very exciting times for regenerative medicine and the kidney.

摘要

近年来，人们越来越清楚地认识到，大多数器官和组织，包括肾脏，都含有常驻的干细胞/祖细胞。干细胞是未分化的、寿命长的细胞，其独特之处在于能够产生分化的子细胞，并通过自我更新保持其干细胞特性。本次会议的主要目标之一是回顾目前对肾脏干细胞的认识，以及在低等脊椎动物和哺乳动物中肾脏再生的机制。演讲者涵盖了广泛的主题，包括干细胞静止、表观遗传学、转录控制回路、去分化、多能干细胞、肾脏祖细胞以及肾脏再生的新的成像方法。在这个互动性非常高的会议结束时，很明显，我们正在进入再生医学和肾脏的非常令人兴奋的时代。