Vivoxid Ltd., Biolinja 12, FI-20750 Turku, Finland.
Acta Biomater. 2013 Jan;9(1):4868-77. doi: 10.1016/j.actbio.2012.08.052. Epub 2012 Sep 7.
An in vitro degradation study of three bioresorbable glass fiber-reinforced poly(l-lactide-co-dl-lactide) (PLDLA) composites was carried out in simulated body fluid (SBF), to simulate body conditions, and deionized water, to evaluate the nature of the degradation products. The changes in mechanical and chemical properties were systematically characterized over 52 weeks dissolution time to determine the degradation mechanism and investigate strength retention by the bioresorbable glass fiber-reinforced PLDLA composite. The degradation mechanism was found to be a combination of surface and bulk erosion and does not follow the typical core-accelerated degradation mechanism of poly(α-hydroxyacids). Strength retention by bioresorbable glass fiber-reinforced PLDLA composites can be tailored by changing the oxide composition of the glass fibers, but the structure-property relationship of the glass fibers has to be understood and controlled so that the phenomenon of ion leaching can be utilized to control the degradation rate. Therefore, these high performance composites are likely to open up several new possibilities for utilizing resorbable materials in clinical applications which could not be realized in the past.
在模拟体液(SBF)中进行了三种生物可降解玻璃纤维增强聚(L-丙交酯-co-DL-丙交酯)(PLDLA)复合材料的体外降解研究,以模拟体内条件,并在去离子水中进行评估降解产物的性质。在 52 周的溶解时间内,系统地对机械和化学性能的变化进行了表征,以确定降解机制并研究生物可降解玻璃纤维增强 PLDLA 复合材料的强度保持率。发现降解机制是表面和体相侵蚀的组合,并不遵循聚(α-羟基酸)的典型核心加速降解机制。通过改变玻璃纤维的氧化物组成,可以调整生物可降解玻璃纤维增强 PLDLA 复合材料的强度保持率,但是必须理解和控制玻璃纤维的结构-性能关系,以便利用离子浸出现象来控制降解速率。因此,这些高性能复合材料可能会为临床应用中可吸收材料的使用开辟一些过去无法实现的新可能性。