用于组织再生的（聚醚醚酮/聚乙醇酸）-羟基磷灰石支架的表征及生物活性评价

Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration.

作者信息

Shuai Cijun, Shuai Chenying, Wu Ping, Yuan Fulai, Feng Pei, Yang Youwen, Guo Wang, Fan Xiaohan, Su Ting, Peng Shuping, Gao Chengde

机构信息

State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China.

State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China.

出版信息

Materials (Basel). 2016 Nov 18;9(11):934. doi: 10.3390/ma9110934.

Bioactivity and biocompatibility are crucial for tissue engineering scaffolds. In this study, hydroxyapatite (HAP) was incorporated into polyetheretherketone/polyglycolicacid (PEEK/PGA) hybrid to improve its biological properties, and the composite scaffolds were developed via selective laser sintering (SLS). The effects of HAP on physical and chemical properties of the composite scaffolds were investigated. The results demonstrated that HAP particles were distributed evenly in PEEK/PGA matrix when its content was no more than 10 wt %. Furthermore, the apatite-forming ability became better with increasing HAP content after immersing in simulated body fluid (SBF). Meanwhile, the composite scaffolds presented a greater degree of cell attachment and proliferation than PEEK/PGA scaffolds. These results highlighted the potential of (PEEK/PGA)-HAP scaffolds for tissue regeneration.