Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Am J Obstet Gynecol. 2012 Dec;207(6):473.e1-7. doi: 10.1016/j.ajog.2012.08.025. Epub 2012 Aug 17.
Chorioamnionitis can cause severe complications for the infant; therefore, characterization of the risk of recurrence and identification of the factors that modify it are clinically relevant to pregnant women and their providers.
The risk of recurrence was examined in a retrospective population-based cohort study with the use of birth certificate and delivery hospitalization discharge data from Washington State for the years 1989-2008.
Women who had chorioamnionitis in their first deliveries were 3.43 times as likely to have chorioamnionitis in their second deliveries as were women who did not have chorioamnionitis in their first deliveries (95% confidence interval [CI], 2.67-4.42; P < .001). Smoking status modified this association (smokers: odds ratio, 1.38 [95% CI, 0.62-3.08]; nonsmokers: odds ratio, 3.80 [95% CI, 2.88-5.00]).
These data provide strong evidence for the occurrence of repeat chorioamnionitis; the association is strongest in women who do not smoke during pregnancy.
绒毛膜羊膜炎可导致婴儿出现严重并发症；因此，对其复发风险进行特征描述，并确定可改变其风险的因素，这对于孕妇及其医护人员来说具有重要的临床意义。
本研究采用回顾性基于人群的队列研究，使用了 1989 年至 2008 年华盛顿州的出生证明和分娩住院数据，对复发风险进行了研究。
与首次分娩中未发生绒毛膜羊膜炎的女性相比，首次分娩中发生绒毛膜羊膜炎的女性再次分娩时发生绒毛膜羊膜炎的可能性是其 3.43 倍（95%置信区间[CI]，2.67-4.42；P<0.001）。吸烟状况改变了这种关联（吸烟者：比值比[OR]，1.38[95%CI，0.62-3.08]；不吸烟者：OR，3.80[95%CI，2.88-5.00]）。
这些数据为重复发生绒毛膜羊膜炎提供了有力证据；在怀孕期间不吸烟的女性中，这种关联最强。
