脉冲皮质类固醇治疗斑秃：10 年后的长期结果。

Pulse corticosteroid therapy for alopecia areata: long-term outcome after 10 years.

机构信息

Department of Dermatology, University Hospital of Lille, Hôpital Claude-Huriez, Lille, France.

出版信息

Dermatology. 2012;225(1):81-7. doi: 10.1159/000341523. Epub 2012 Sep 10.

DOI:10.1159/000341523

PMID:22964518

Abstract

BACKGROUND

Few data are available concerning the efficiency of pulse corticosteroids in alopecia areata (AA).

OBJECTIVE

Our purpose was to assess the long-term outcomes of patients treated with methylprednisolone bolus.

METHODS

This study included 60 patients treated between 1995 and 2000. The short-term outcomes were analyzed in 2000. The long-term assessment of 30 patients was performed in 2010 by phone questionnaire.

RESULTS

Significant hair regrowth was observed in 10/30 patients at 6 months after the bolus treatment. Half of the plurifocalis AA patients were responders at 6 months, but less than one quarter of alopecia totalis (AT) and alopecia universalis (AU) patients responded. Long-term outcomes were assessed after a mean duration of 12.3 years; 8/10 initial responders had mild or no disease, and 14/20 initial nonresponders had severe AA.

CONCLUSIONS

This study confirmed the low efficiency, both short- and long-term, of this treatment for AT and AU.

摘要

背景

有关脉冲皮质类固醇治疗斑秃（AA）的疗效数据很少。

目的

我们旨在评估甲泼尼龙冲击治疗的长期疗效。

方法

本研究纳入了 1995 年至 2000 年间接受治疗的 60 例患者。2000 年对短期疗效进行了分析。2010 年通过电话问卷调查对 30 例患者进行了长期评估。

结果

冲击治疗后 6 个月，10/30 例患者的毛发明显再生。脉冲皮质类固醇治疗 6 个月后，50%的多灶性 AA 患者有应答，但不到四分之一的全秃（AT）和普秃（AU）患者有应答。平均 12.3 年后进行长期疗效评估；10 例初始应答者中有 8 例病情轻微或无，20 例初始无应答者中有 14 例病情严重。