斑秃的脉冲式皮质类固醇疗法：139例患者的研究

Pulse corticosteroid therapy for alopecia areata: study of 139 patients.

作者信息

Nakajima Takeshi, Inui Shigeki, Itami Satoshi

机构信息

Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.

出版信息

Dermatology. 2007;215(4):320-4. doi: 10.1159/000107626.

DOI:10.1159/000107626

PMID:17911990

Abstract

BACKGROUND/AIM: Recent reports of pulse corticosteroid therapy for alopecia areata (AA) show its efficacy for patients with a history of < or = 1 year but not for recalcitrant cases or alopecia totalis/universalis. The purpose of this study was to evaluate the efficacy and safety of pulse corticosteroid therapy for recent-onset AA patients.

METHOD

A total of 139 severe AA patients aged >15 years were included in this study. The duration from the onset of active hair loss was within 12 months for 125 (89.9%) of those patients.

RESULTS

Of the patients, 72.7% had hair loss on > 50% of their scalp area. Among the recent-onset group (duration of AA < or = 6 months), 59.4% were good responders (> 75% regrowth of alopecia lesions), while 15.8% with > 6 months duration showed a good response. Recent-onset AA patients with less severe disease (< or = 50% hair loss) responded at a rate of 88.0%, but only 21.4% of recent-onset patients with 100% hair loss responded. No serious adverse effects were observed.

摘要

背景/目的：近期有关斑秃（AA）脉冲式皮质类固醇治疗的报告显示，该疗法对病程≤1年的患者有效，但对顽固性病例或全秃/普秃患者无效。本研究旨在评估脉冲式皮质类固醇治疗近期发病的AA患者的疗效和安全性。

方法

本研究共纳入139例年龄>15岁的重度AA患者。其中125例（89.9%）患者从活动性脱发开始的病程在12个月内。

结果

这些患者中，72.7%的头皮脱发面积超过50%。在近期发病组（AA病程≤6个月）中，59.4%为良好反应者（脱发皮损再生>75%），而病程>6个月的患者中，15.8%有良好反应。病情较轻（脱发≤50%）的近期发病AA患者的有效率为88.0%，但100%脱发的近期发病患者中只有21.4%有反应。未观察到严重不良反应。