传染性单核细胞增多症中的严重中性粒细胞减少症。
Severe neutropenia in infectious mononucleosis.
作者信息
Hammond W P, Harlan J M, Steinberg S E
出版信息
West J Med. 1979 Aug;131(2):92-7.
Mild neutropenia is a well-known concomitant of infectious mononucleosis caused by the Epstein-Barr virus (EBV) occurring in the first weeks of illness. However, severe neutropenia (less than 200 polymorphonuclear leukocytes per mul) is not generally regarded as a complication of infectious mononucleosis. Three patients were seen with severe neutropenia and EBV infection, and an additional eight cases were found in the literature. In two of the latter cases the neutropenia was fatal. In the 11 cases the severe neutropenia began 14 to 40 days after illness and usually lasted for three to seven days. At the time of severe neutropenia, studies of marrow specimens showed increased proportions of promyelocytes and myelocytes. Our data suggest that EBV infection is the proximate cause of the severe neutropenia in some patients with infectious mononucleosis and that in such cases close observation and early treatment of suspected superinfections is necessary.
轻度中性粒细胞减少是由爱泼斯坦-巴尔病毒（EBV）引起的传染性单核细胞增多症在发病最初几周出现的一种常见伴随症状。然而，严重中性粒细胞减少（每微升少于200个多形核白细胞）通常不被视为传染性单核细胞增多症的并发症。我们观察到3例严重中性粒细胞减少合并EBV感染的患者，另外在文献中发现8例。在后两例中，中性粒细胞减少是致命的。在这11例中，严重中性粒细胞减少在发病后14至40天开始，通常持续三至七天。在严重中性粒细胞减少时，骨髓标本研究显示早幼粒细胞和中幼粒细胞比例增加。我们的数据表明，EBV感染是一些传染性单核细胞增多症患者严重中性粒细胞减少的直接原因，在这种情况下，对疑似重叠感染进行密切观察和早期治疗是必要的。
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