在血脂异常患者中，残余样颗粒胆固醇与γ-谷氨酰转移酶之间的关系。
Association between remnant-like particle cholesterol and gamma-glutamyltransferase in dyslipidemic patients.
机构信息
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
出版信息
Med Princ Pract. 2013;22(2):189-93. doi: 10.1159/000341767. Epub 2012 Sep 6.
OBJECTIVE
To investigate the correlation between gamma-glutamyltransferase (GGT) and remnant-like particle cholesterol (RLP-C) in dyslipidemic patients.
SUBJECTS AND METHODS
General cardiometabolic variables, plus serum GGT and RLP-C levels, were measured in 118 dyslipidemic patients (59 males, mean age 58 ± 13 years). Correlation analyses of GGT with other variables, including RLP-C, were performed.
RESULTS
The median levels (interquartile ranges) of RLP-C and GGT were 0.21 mmol/l (0.14-0.35) and 26 IU/l (17-39), respectively. A stepwise multiple regression analysis revealed an independent, significant and positive correlation between GGT and RLP-C (β = 0.351, p < 0.001), followed by male gender and BMI.
CONCLUSION
There was a significant positive association between GGT and RLP-C, thereby indicating that the association between GGT and cardiovascular disease may be partly due to the interaction with RLP-C in dyslipidemic patients. Further research is therefore warranted to confirm the observed relationship.
目的
探讨血脂异常患者γ-谷氨酰转移酶（GGT）与残粒样脂蛋白胆固醇（RLP-C）之间的相关性。
对象与方法
对 118 例血脂异常患者（59 例男性，平均年龄 58±13 岁）进行了一般心血管代谢变量，以及血清 GGT 和 RLP-C 水平的检测。对 GGT 与包括 RLP-C 在内的其他变量之间的相关性进行了分析。
结果
RLP-C 和 GGT 的中位数（四分位数间距）分别为 0.21mmol/l（0.14-0.35）和 26IU/l（17-39）。逐步多元回归分析显示，GGT 与 RLP-C 之间存在独立、显著和正相关（β=0.351，p<0.001），其次是男性性别和 BMI。
结论
GGT 与 RLP-C 之间存在显著的正相关，这表明 GGT 与心血管疾病之间的关联可能部分归因于血脂异常患者中 GGT 与 RLP-C 的相互作用。因此，有必要进行进一步的研究来证实观察到的这种关系。
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