Department of Epidemiology, Capital Institute of Pediatrics, Beijing, People's Republic of China.
Diab Vasc Dis Res. 2013 May;10(3):202-7. doi: 10.1177/1479164112455535. Epub 2012 Sep 10.
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood. We examined the associations of the SNPs (rs11066001 and rs3782886) in BRAP with metabolic syndrome (MetS), which is a strong predictor of cardiovascular disease, and potential associations between these SNPs and factors related to inflammation. There were significant associations of both the SNPs with MetS [rs11066001, odds ratio (OR) 0.70, 95% confidence interval (CI) 0.51-0.96, p = 0.028; rs3782886, OR 0.69, 95% CI 0.50-0.94, p = 0.020] under a dominant model after age and gender adjustment. Both SNPs were significantly associated with waist circumference, plasma glucose, glycated haemoglobin, triglycerides and nonesterified fatty acid. Our data provide evidence that the SNPs (rs11066001 and rs3782886) in BRAP decrease the risk of MetS, and associations of the SNPs with various components of MetS are different. Moreover, there are significant associations of both the SNPs with nonesterified fatty acid that could be involved in the inflammatory activity of electronegative low-density lipoprotein.
乳腺癌抑制蛋白相关蛋白 (BRAP) 基因中的单核苷酸多态性 (SNPs) 与冠状动脉疾病显著相关，但分子机制尚不清楚。我们研究了 BRAP 中 SNP(rs11066001 和 rs3782886) 与代谢综合征 (MetS) 的关联，MetS 是心血管疾病的强烈预测因子，以及这些 SNP 与与炎症相关的因素之间的潜在关联。这两个 SNP 与 MetS 都存在显著关联[rs11066001，比值比 (OR) 0.70，95%置信区间 (CI) 0.51-0.96，p = 0.028；rs3782886，OR 0.69，95%CI 0.50-0.94，p = 0.020]，在年龄和性别调整后的显性模型下。这两个 SNP 与腰围、血浆葡萄糖、糖化血红蛋白、甘油三酯和非酯化脂肪酸均有显著关联。我们的数据提供了证据表明，BRAP 中的 SNPs(rs11066001 和 rs3782886) 降低了 MetS 的风险，并且 SNP 与 MetS 的各种成分之间的关联是不同的。此外，这两个 SNP 与非酯化脂肪酸都有显著的关联，这可能与电负性低密度脂蛋白的炎症活性有关。
