Department of Biology, Irving K. Barber School of Arts and Sciences, University of British Columbia Okanagan Campus, Kelowna, BC, Canada.
Inflammopharmacology. 2012 Dec;20(6):297-306. doi: 10.1007/s10787-012-0149-1. Epub 2012 Sep 11.
More than 30 years ago, auranofin was developed for the treatment of rheumatoid arthritis as a substitution for the injectable gold compounds aurothiomalate and aurothioglucose. Both the ease of oral administration over intramuscular injections and more potent anti-inflammatory effects in vitro made auranofin seem like an excellent substitute for the traditional injectable gold compounds. Despite efficacy in the treatment of both rheumatoid arthritis and psoriasis, currently, auranofin is seldom used as a treatment for patients with rheumatoid arthritis as more novel anti-rheumatic medications have become available. Despite the decline in its clinical applications, research on auranofin has continued as it shows promise in the treatment of several different diseases. In recent years, advances in technology have allowed researchers to use molecular techniques to identify novel mechanisms of action of auranofin. Additionally, researchers are discovering potential new applications of auranofin. Dual inhibition of inflammatory pathways and thiol redox enzymes by auranofin makes it a new candidate for cancer therapy and treating microbial infections. This review will summarize recently obtained data on the mechanisms of action of auranofin, and potential new applications of auranofin in the treatment of various diseases, including several types of leukaemia, carcinomas, and parasitic, bacterial, and viral infections.
30 多年前，金诺芬被开发用于治疗类风湿关节炎，以替代可注射的金化合物金硫代苹果酸和金硫代葡萄糖。口服比肌肉注射更方便，体外更有效的抗炎作用，使金诺芬似乎是传统可注射金化合物的极佳替代品。尽管金诺芬在治疗类风湿关节炎和银屑病方面都有效，但由于出现了更多新型的抗风湿药物，目前金诺芬很少用于治疗类风湿关节炎患者。尽管其临床应用有所下降，但对金诺芬的研究仍在继续，因为它在治疗几种不同疾病方面显示出了前景。近年来，技术的进步使研究人员能够使用分子技术来确定金诺芬的新作用机制。此外，研究人员正在发现金诺芬的潜在新应用。金诺芬对炎症途径和硫醇氧化还原酶的双重抑制作用使其成为癌症治疗和治疗微生物感染的新候选药物。本综述将总结金诺芬作用机制的最新研究数据，以及金诺芬在治疗各种疾病方面的潜在新应用，包括几种白血病、癌和寄生虫、细菌和病毒感染。
