Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222, Australia.
Metallomics. 2011 Sep;3(9):863-73. doi: 10.1039/c1mt00062d. Epub 2011 Jul 14.
The application of gold in medicine is traceable for several thousand years and Au(i) compounds have been used clinically to treat rheumatoid arthritis since the last century. Recently research into gold-based drugs for a range of human diseases has seen a renaissance. Old as well as new Au(i) and Au(iii) compounds have been used and designed with an aim of targeting cellular components that are implicated in the onset or progression of cancers, rheumatoid arthiritis, viral and parasitic diseases. In addition, new disease targets have been found for gold compounds that have given insight into the mechanism of action of these compounds, as well as in the molecular pathophysiology of human diseases. Here we discuss the rationale for the design and use of gold compounds that have specific and selective targets in cells to alleviate the symptoms of a range of human diseases. We summarise the most recent findings in this research and our own discoveries to show that gold compounds can be developed to become versatile and powerful drugs for diseases caused by dysfunction of selenol and thiol containing proteins.
金在医学中的应用可以追溯到几千年前，自上个世纪以来，Au(i)化合物就被临床用于治疗类风湿性关节炎。最近，针对一系列人类疾病的基于金的药物研究出现了复兴。旧的和新的 Au(i)和 Au(iii)化合物已经被使用和设计，旨在针对与癌症、类风湿性关节炎、病毒和寄生虫疾病的发生或进展有关的细胞成分。此外，还为金化合物找到了新的疾病靶点，这些靶点为这些化合物的作用机制以及人类疾病的分子病理生理学提供了深入了解。在这里，我们讨论了设计和使用金化合物的基本原理，这些化合物在细胞中有特定和选择性的靶点，以缓解一系列人类疾病的症状。我们总结了这方面的最新研究发现和我们自己的发现，表明金化合物可以被开发成为治疗由含硒和硫醇蛋白功能障碍引起的疾病的多功能有效药物。
