George W. Woodruff School of Mechanical Engineering, and The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Ann Biomed Eng. 2013 Feb;41(2):238-49. doi: 10.1007/s10439-012-0648-7. Epub 2012 Sep 11.
An investigation of margination dependence on hematocrit, platelet shape, and viscosity ratio of plasma to cytoplasm is presented. Whole blood is modeled as a suspension of deformable red blood cells (RBCs) and rigid platelets in a viscous liquid. The fluid phase is simulated using the lattice-Boltzmann method, the RBC membranes are modeled with a coarse-grained spectrin-link method, and the dynamics of rigid particles are updated using Newton's equations of motion for axisymmetric shapes. The results emphasize that an increase in hematocrit increases the rate of margination. The viscosity ratio between the interior cytoplasm and suspending fluid can considerably alter the rate of margination. The aspect ratio of surrogate platelet particles influences the rate of margination as well. Spherical particles tend to migrate more quickly than disks. Highly viscous or rigid RBCs slow down margination.
本文研究了血液的切变率依赖于血细胞比容、血小板形状和血浆与细胞质的黏度比。将全血模拟为变形红细胞（RBC）和刚性血小板在粘性液体中的悬浮液。使用晶格玻尔兹曼方法模拟流体相，使用粗粒化血影蛋白连接方法模拟 RBC 膜，使用牛顿轴对称运动方程更新刚性粒子的动力学。结果强调了血细胞比容的增加会加快靠边聚集的速度。内部细胞质和悬浮液之间的黏度比可以极大地改变靠边聚集的速度。替代血小板粒子的纵横比也会影响靠边聚集的速度。球形粒子比圆盘状粒子更倾向于快速迁移。高粘度或刚性 RBC 会减缓靠边聚集的速度。
