化学程序化抗体是一种长效且强效的流感神经氨酸酶抑制剂。
A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Chembiochem. 2012 Oct 15;13(15):2191-5. doi: 10.1002/cbic.201200439. Epub 2012 Sep 10.
Abstract
Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.
摘要
设计抗流感策略
研发出一种新型强效神经氨酸酶抑制剂，可维持抗体的长期系统暴露和神经氨酸酶抑制剂扎那米韦的治疗活性。该策略可为治疗和预防流感 A 病毒提供一类很有前景的新型药物，并验证了酶抑制剂作为合成免疫学中的编程剂的作用。
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