Department of Otorhinolaryngology-Head and Neck Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.
Laryngoscope. 2012 Dec;122(12):2723-7. doi: 10.1002/lary.23580. Epub 2012 Sep 10.
OBJECTIVES/HYPOTHESIS: The aim of this study was to assess the efficacy of primary surgical treatment in the management of T3 glottic carcinomas.
Retrospective clinical study.
A retrospective evaluation of the records for all patients treated with primary surgery for T3 glottic carcinomas at a tertiary referral center between 1980 and 2005 was carried out. Data for the 5-year disease-specific survival (DSS) were assessed, as well as local control rates in relation to vocal cord immobility, N classification, choice of surgical modality, and adjuvant therapy. Patients who underwent partial laryngectomy were also evaluated in relation to organ preservation and the rate of permanent tracheotomies.
The 5-year DSS in the 120 patients was 78.3%. Positive neck disease was shown to be a significant negative prognostic factor. Organ preservation was achieved in 90.1% of the patients who underwent partial laryngectomy and in 50% of the overall patient group. The occult metastasis rate was 14%.
Primary surgical treatment is an effective modality against T3 glottic carcinomas. Partial laryngectomy is a reliable method in carefully selected cases. Low complication rates can be expected.
目的/假设：本研究旨在评估原发性手术治疗 T3 声门型喉癌的疗效。
回顾性临床研究。
对 1980 年至 2005 年间在一家三级转诊中心接受原发性手术治疗 T3 声门型喉癌的所有患者的记录进行了回顾性评估。评估了 5 年疾病特异性生存率（DSS），以及与声带固定、N 分类、手术方式选择和辅助治疗相关的局部控制率。还评估了接受部分喉切除术的患者与器官保留和永久性气管切开术的发生率之间的关系。
120 例患者的 5 年 DSS 为 78.3%。颈部疾病阳性被证明是一个显著的预后不良因素。接受部分喉切除术的患者中有 90.1%实现了器官保留，而在整个患者组中这一比例为 50%。隐匿性转移率为 14%。
原发性手术治疗是治疗 T3 声门型喉癌的有效方法。在精心选择的病例中，部分喉切除术是一种可靠的方法。预计并发症发生率低。
