Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland.
J Infect Dis. 2012 Nov 15;206(10):1542-8. doi: 10.1093/infdis/jis568. Epub 2012 Sep 10.
The measles-mumps-rubella (MMR) vaccine is effective in eliciting a good antibody response. In addition to the amount of antibodies, the avidity of these antibodies might be important in protecting against disease.
The amount of circulating antibodies for measles, mumps, and rubella was measured with enzyme immunoassays, and the avidity of these antibodies was determined by urea dissociation. Three groups of twice-MMR-vaccinated individuals and 1 group of naturally infected individuals were studied. One vaccinated group (n = 71) was studied 6 months and 20 years after a second MMR vaccination.
The antibody avidity indexes were high for measles and rubella but low for mumps. Twenty years after a second MMR vaccination, antibody levels for all 3 viruses waned. Also, the mean avidity index decreased by 8% for measles, 24% for mumps, and remained unchanged for rubella. Antibody avidity correlated with antibody concentration for measles. There was partial correlation for rubella and no correlation for mumps.
Measles and rubella induced high-avidity antibodies and mumps induced low-avidity antibodies after both vaccination and natural infection. Waning of both the concentration as well as the avidity of antibodies might contribute to measles and mumps infections in twice-MMR-vaccinated individuals.
麻疹-腮腺炎-风疹（MMR）疫苗可有效引发良好的抗体反应。除了抗体数量外，这些抗体的亲合力在预防疾病方面可能也很重要。
采用酶联免疫吸附法检测麻疹、腮腺炎和风疹的循环抗体量，并通过尿素解离测定这些抗体的亲合力。研究了三组两次 MMR 疫苗接种者和一组自然感染者。一组接种者（n = 71）在第二次 MMR 疫苗接种后 6 个月和 20 年进行了研究。
麻疹和风疹的抗体亲合力指数较高，但腮腺炎的抗体亲合力指数较低。第二次 MMR 疫苗接种 20 年后，所有 3 种病毒的抗体水平均下降。此外，麻疹的平均亲合力指数下降了 8%，腮腺炎下降了 24%，风疹则保持不变。抗体亲合力与麻疹抗体浓度相关。风疹存在部分相关性，腮腺炎则无相关性。
无论是接种疫苗还是自然感染，麻疹和风疹均可诱导高亲合力抗体，而腮腺炎则诱导低亲合力抗体。两次 MMR 疫苗接种者中，抗体浓度和亲合力的下降可能导致麻疹和腮腺炎感染。
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