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The mechanism of action of antidepressant treatments: basic aspects.

作者信息

Green A R

机构信息

Astra Neuroscience Research Unit, London, G. B.

出版信息

Pharmacopsychiatry. 1988 Jan;21(1):3-5. doi: 10.1055/s-2007-1014636.

DOI:10.1055/s-2007-1014636
PMID:2834759
Abstract

Antidepressant drugs and electroconvulsive shock (ECS) have, following repeated administration, been shown to produce diverse biochemical changes in rodent brain. Most drugs and ECS decrease the density of beta-adrenoceptors in the forebrain and several drugs and ECS decrease the function of alpha 2-adrenoceptors. Antidepressant treatments also attenuate the temperature response to the 5-HT1A agonist 8-OH-DPAT but 5-HT2-receptor number and function are both decreased by antidepressant drugs but increased by ECS. GABAB receptor number and function are increased by antidepressant treatments. It remains unclear which of these changes are involved in the therapeutic mechanism of action.

摘要

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Psychopharmacology (Berl). 1993;110(1-2):140-4. doi: 10.1007/BF02246963.
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Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.长期服用抗抑郁药和抗精神病药对中枢神经系统受体的影响。
Cell Mol Neurobiol. 1989 Mar;9(1):1-44. doi: 10.1007/BF00711441.
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Electroconvulsive treatment attenuates behavioral response to SKF 38393 in reserpine-treated mice.
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Psychopharmacology (Berl). 1990;100(1):135-7. doi: 10.1007/BF02245805.