Kodama Junichi, Seki Noriko, Yanai Hiroyuki, Kusumoto Tomoyuki, Nakamura Keiichiro, Hongo Atsushi, Hiramatsu Yuji
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Oncol Lett. 2010 Mar;1(2):243-245. doi: 10.3892/ol_00000043. Epub 2010 Mar 1.
Endometrial carcinomas producing α-fetoprotein (AFP) are extremely rare. We report a case of AFP-producing, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. A 59-year-old multiparous woman presented with abdominal swelling. The serum level of AFP was 1292.8 ng/ml. Magnetic resonance images of the pelvis showed a markedly enlarged uterus, with a tumor growing exophytically within the endometrial cavity. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The histopathological examination demonstrated a Stage IIA, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. The endometrioid adenocarcinoma cells were partly positive for AFP immunoreactivity. The patient received adjuvant chemotherapy and was disease-free 60 months after the operation. This case confirms the existence of AFP-producing endometrioid adenocarcinomas without hepatoid features.
产生甲胎蛋白（AFP）的子宫内膜癌极为罕见。我们报告一例产生AFP的2级子宫内膜样腺癌，无明显的肝样成分。一名59岁经产妇因腹部肿胀就诊。血清AFP水平为1292.8 ng/ml。盆腔磁共振成像显示子宫明显增大，子宫内膜腔内有一外生性生长的肿瘤。行全腹子宫切除术及双侧输卵管卵巢切除术。组织病理学检查显示为IIA期、2级子宫内膜样腺癌，无明显肝样成分。子宫内膜样腺癌细胞AFP免疫反应部分呈阳性。患者接受辅助化疗，术后60个月无疾病复发。该病例证实了无肝样特征的产生AFP的子宫内膜样腺癌的存在。
